C1307 字2:26新闻报道英国腔发布于 2026年5月30日 · 更新于 2026年5月30日

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Landmark NHS Blood Test Trial for Multiple Cancers Falls Short of Primary Objective

具有里程碑意义的英国国家医疗服务体系多癌症血液检测临床试验未达到主要目标

A pioneering blood test designed to detect over fifty types of cancer has failed to achieve its primary goal in a large-scale clinical trial involving approximately 142,000 NHS patients.

一项旨在检测五十多种癌症的开拓性血液测试，在一项涉及约 142,000 名英国国家医疗服务体系患者的大规模临床试验中，未能实现其主要目标。

The results, unveiled at the American Society of Clinical Oncology's annual conference in Chicago, revealed that the Galleri test did not significantly reduce late-stage cancer diagnoses.

在芝加哥举行的美国临床肿瘤学会年会上揭晓的结果显示，Galleri 测试并未显著减少晚期癌症的诊断。

Had the trial succeeded, it would have marked a transformative breakthrough in medical research methodology and early cancer detection worldwide.

若该试验取得成功，它将在医学研究方法论和全球早期癌症检测领域标志着一项变革性的突破。

The study, which constitutes the world's first randomised controlled trial of a multi-cancer early detection test, enrolled 142,942 asymptomatic participants aged fifty to seventy-seven.

这项研究构成了全球首例针对多种癌症早期检测测试的随机对照试验，招募了 142,942 名年龄介于 50 至 77 岁之间的无症状受试者。

Each participant underwent annual blood draws over three years while continuing to receive standard cancer screening.

每位参与者在持续接受标准癌症筛查的同时，在三年的时间里每年进行抽血。

Researchers had hypothesised that supplementing conventional screening with the Galleri blood test could shift cancer diagnosis to earlier, more treatable stages, thereby improving patient outcomes substantially.

研究人员曾假设，在传统筛查中加入 Galleri 血液检测可以将癌症诊断推向更早、更易治疗的阶段，从而显著改善患者的预后。

Doctor Julie Gralow, who serves as the chief medical officer and executive vice-president of the oncology society, cautioned against drawing overly simplistic conclusions.

担任美国临床肿瘤学会首席医学官兼执行副总裁的朱莉·格拉洛博士警告，不要得出过于简单化的结论。

She acknowledged that while the data exhibited some encouraging trends toward tumour downstaging, the trial ultimately did not meet its predefined primary endpoint.

她承认，虽然数据在肿瘤降期方面呈现出一些令人鼓舞的趋势，但该试验最终未能达到其预设的主要终点。

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Not only did the test fail to achieve statistical significance in reducing late-stage diagnoses, but it also raised fundamental questions about the viability of current multi-cancer detection approaches.

这项测试不仅未能达到减少晚期诊断的统计显著性，还引发了关于目前多癌检测方法可行性的根本性疑问。

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One senior oncology delegate, who spoke to journalists on condition of anonymity, characterised the outcome far more bluntly.

一名要求匿名的资深肿瘤学代表在接受记者采访时，对结果的评价更为直白。

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The delegate reportedly stated that the clinical trial had unequivocally flopped, describing the failure as clear and simple.

据报道，该代表表示临床试验已明确失败，并形容这次失败是显而易见且不争的事实。

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Such candid assessments underscore the growing scepticism among specialists regarding whether a single blood test can reliably revolutionise cancer diagnosis across dozens of malignancies.

如此坦率的评估凸显了专家们对于单一血液检测是否能可靠地彻底改变数十种恶性肿瘤诊断的日益增长的怀疑。

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Nevertheless, proponents of the technology argue that the trial's secondary findings warrant further investigation before definitive judgments are rendered.

尽管如此，该技术的支持者主张，试验的次要发现值得在做出最终判决之前进行进一步调查。

Trial of multi-cancer blood test among 142,000 NHS patients fails to meet main aim14.2万名NHS患者参与的多癌种血液检测临床试验未达主要目标

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