C1311 字3:05新闻报道美国腔发布于 2026年8月12日 · 更新于 2026年8月12日

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A groundbreaking initiative worth twenty million pounds has been launched at the University of Cambridge to grow miniature human organs from patients' cells.

劍橋大學啟動了一項價值兩千萬英鎊的開創性倡議，旨在利用患者的細胞培養微型人體器官。

These laboratory-cultivated structures, known as organoids, are intended to revolutionise how pharmaceutical companies conduct drug testing on human tissues.

這些在實驗室培育的結構（被稱為類器官）旨在徹底改變製藥公司對人類組織進行藥物測試的方式。

The project represents a decisive shift away from conventional animal-based models toward what researchers have characterised as a more precise alternative methodology.

該計畫代表著從傳統的動物模型，明確轉向研究人員所描述的一種更精確的替代方法。

Scientists at the Cambridge Stem Cell Institute plan to use cells obtained from NHS patients to cultivate tiny clumps of tissue.

劍橋幹細胞研究所的科學家們計劃利用從英國國家醫療服務體系患者身上取得的細胞，來培養微小的組織塊。

Each organoid, though smaller than a millimetre, can replicate essential features of full-scale organs, including how they deteriorate under disease conditions.

每個類器官雖然小於一公釐，卻能複製完整器官的關鍵特徵，包括它們在疾病狀況下如何惡化。

Professor Matthias Zilbauer, a specialist in paediatric gastroenterology, emphasised that this approach would substantially reduce the number of animals used in medical research.

兒童腸胃科專家馬蒂亞斯·齊爾鮑爾教授強調，這種方法將大幅減少醫學研究中所使用的動物數量。

However, Zilbauer cautioned that animal experimentation would not be eliminated entirely in the foreseeable future.

然而，齊爾鮑爾警告說，動物實驗在可預見的未來不會被完全消除。

Certain physiological processes, he argued, still cannot be adequately modelled using organoids alone.

他主張，某些生理過程仍然無法僅靠類器官得到充分的模擬。

Nevertheless, the reduction in animal use is expected to be significant, as these tissue-based models offer a more direct window into human pathology than any mouse ever could.

儘管如此，減少使用動物數量的效果預計將相當顯著，因為這些基於組織的模型比任何老鼠都更能提供直接了解人類病理學的窗口。

#10

One of the most compelling advantages of organoids lies in their capacity to capture individual patient variation.

類器官最引人注目的優勢之一，在於它們能夠捕捉個別患者之間的差異。

#11

By growing tissues from different patients, researchers can determine whether a given drug candidate reverses pathological changes universally or only in a subset of individuals.

透過培育來自不同患者的組織，研究人員可以確定某個候選藥物是在所有個體中都能通用地逆轉病理變化，還是僅在少數特定人群中有效。

#12

Were this technology to become standardised, it could fundamentally transform personalised medicine and accelerate the identification of ineffective treatments before costly clinical trials commence.

這項技術若能實現標準化，將能從根本上改變個性化醫療，並在昂貴的臨床試驗開始前，加速識別無效的治療方法。

#13

Researchers have been cultivating organoids for over a decade, yet standardisation has remained elusive until now.

研究人員培養類器官已有十多年的時間，然而標準化至今仍遙不可及。

#14

The Cambridge project aims to create reproducible, high-quality models that any laboratory worldwide could utilise.

這個劍橋計畫旨在打造可重複製作且高品質的模型，供全球任何實驗室使用。

#15

Should the initiative prove successful, it would mark a watershed moment not only for drug testing but also for the broader landscape of medical research and ethical scientific practice.

倘若該倡議被證明是成功的，它將不僅是藥物測試領域，更會是更廣泛的醫學研究與倫理科學實踐範疇中的一個分水嶺時刻。

‘A mouse can’t tell us what works’: UK scientists to grow miniature human organs for drug testing

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