C1311 語3:05ニュースレポートアメリカ英語2026年8月12日公開 · 2026年8月12日更新

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A groundbreaking initiative worth twenty million pounds has been launched at the University of Cambridge to grow miniature human organs from patients' cells.

These laboratory-cultivated structures, known as organoids, are intended to revolutionise how pharmaceutical companies conduct drug testing on human tissues.

The project represents a decisive shift away from conventional animal-based models toward what researchers have characterised as a more precise alternative methodology.

Scientists at the Cambridge Stem Cell Institute plan to use cells obtained from NHS patients to cultivate tiny clumps of tissue.

Each organoid, though smaller than a millimetre, can replicate essential features of full-scale organs, including how they deteriorate under disease conditions.

Professor Matthias Zilbauer, a specialist in paediatric gastroenterology, emphasised that this approach would substantially reduce the number of animals used in medical research.

However, Zilbauer cautioned that animal experimentation would not be eliminated entirely in the foreseeable future.

Certain physiological processes, he argued, still cannot be adequately modelled using organoids alone.

Nevertheless, the reduction in animal use is expected to be significant, as these tissue-based models offer a more direct window into human pathology than any mouse ever could.

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One of the most compelling advantages of organoids lies in their capacity to capture individual patient variation.

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By growing tissues from different patients, researchers can determine whether a given drug candidate reverses pathological changes universally or only in a subset of individuals.

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Were this technology to become standardised, it could fundamentally transform personalised medicine and accelerate the identification of ineffective treatments before costly clinical trials commence.

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Researchers have been cultivating organoids for over a decade, yet standardisation has remained elusive until now.

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The Cambridge project aims to create reproducible, high-quality models that any laboratory worldwide could utilise.

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Should the initiative prove successful, it would mark a watershed moment not only for drug testing but also for the broader landscape of medical research and ethical scientific practice.

‘A mouse can’t tell us what works’: UK scientists to grow miniature human organs for drug testing

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